how to stop taking tirzepatide Mounjaro Safely | Discontinuation Guide 6 Things That Can Happen

Nauck MA, DAlessio DA

Trial design: 2,339 participants Adults with obesity or overweight + at least one weight-related complication Participants did NOT have diabetes Randomized to placebo or retatrutide 4 mg, 9 mg or 12 mg 80-week double-blind trial Pre-specified extension to 104 weeks in participants with BMI 35 Weight loss results at 80 weeks: 4 mg: -19.0% (~47 lbs / 21.4 kg) 9 mg: -25.9% (~64 lbs / 29.2 kg) 12 mg: -28.3% (~70 lbs / 31.9 kg) That degree of weight loss approaches levels traditionally associated with bariatric surgery

Too many people jump straight to a high dose, thinking more is better

Gabay C, Kushner I